Description: Polycystic Kidney Disease, Hardcover by Riella, Christian; Czarnecki, Peter G.; Steinman, Theodore I.; Granger, D. Neil (EDT); Granger, Joey P. (EDT), ISBN 161504762X, ISBN-13 9781615047628, Like New Used, Free shipping in the US This book reviews important aspects of polycystic kidney diseases, the latest scientific understanding of the diseases and syndromes, along with the therapies being developed. Cystic kidney diseases comprise a spectrum of genetic syndromes defined by renal cyst formation and expansion with variable extrarenal manifestations. The most prevalent disorder is the autosomal dominant polycystic kidney disease (ADPKD). It is the most common monogenetic disorder in humans and accounts for of end-stage renal disease (ESRD) cases in the . Patients inevitably progress to ESRD and require renal replacement therapy in the form of dialysis or transplantation. Through advancements in genomics and proteomics approaches, novel genes responsible for cystic diseases have been identified, further expanding our understanding of basic mechanisms of disease pathogenesis. The hallmark among all cystic genetic syndromes is the formation and growth of fluid-filled cysts, which originate from tubular epithelia of nephron segments. Cysts are the disease, and treatment strategies are being developed to target prevention or delay of cyst formation and expansion at an early stage, however no such therapy is currently approved.
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Book Title: Polycystic Kidney Disease
Number of Pages: 47 Pages
Publication Name: Polycystic Kidney Disease
Language: English
Publisher: Morgan & Claypool LIFE Science Publishers
Publication Year: 2017
Subject: Life Sciences / Molecular Biology, Endocrinology & Metabolism, Physiology
Item Height: 0.2 in
Item Weight: 11.2 Oz
Type: Textbook
Subject Area: Science, Medical
Item Length: 9.2 in
Author: Christian Riella, Peter G. Czarnecki, D. Neil Granger, Theodore I. Steinman, Joey P. Granger
Item Width: 7.5 in
Series: Colloquium Series on Integrated Systems Physiology: from Molecule to Function Ser.
Format: Hardcover
