Description: Fanconi Anemia & Oxidative Stress by Giovanni Pagano Fanconi Anemia (FA), a rare genetic disease featuring excess cancer risk and chromosomal instability, has received growing interest after the discovery that one of the defective genes in FA is associated with high-impact diseases such as familial breast cancer and ovary cancers. A well-documented relationship has accumulated in several decades and up to recently, studies have linked FA with a redox imbalance (oxidative stress, OS) in FA cells. The toxicity mechanisms of crosslinking agents (mitomycin C and diepoxybutane) in FA cells, along with the roles of OS-related aldehydes and glutathione in FA and in other diseases, are critically discussed. Also discussed is the proinflammatory state in FA phenotype. Additionally, recent studies have discovered an impairment in the structure and function of mitochondria in FA cell lines, while mitochondrial dysfunction in FA patients has so far been an unexplored field warranting ad hoc investigations.This book provides the readers with up-to-date information and perspectives on Fanconi anemia and oxidative stress that may prompt further elucidation of this intriguing disease, along with working hypotheses in clinical research and patients management. FORMAT Hardcover LANGUAGE English CONDITION Brand New Table of Contents For Complete Table of Contents, please visit our website at: _info.php?products_id=53922 Details ISBN1634822978 Pages 143 Publisher Nova Science Publishers Inc Year 2015 ISBN-10 1634822978 ISBN-13 9781634822978 Format Hardcover Imprint Nova Science Publishers Inc Place of Publication New York Country of Publication United States Edited by Giovanni Pagano DEWEY 616.152 Publication Date 2015-06-01 Subtitle Mechanistic Background & Clinical Prospects Author Giovanni Pagano Short Title Fanconi Anemia and Oxidative Stress Series Cancer Etiology, Diagnosis and Treatments Language English UK Release Date 2015-06-01 AU Release Date 2015-06-01 NZ Release Date 2015-06-01 US Release Date 2015-06-01 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:135714538;
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ISBN-13: 9781634822978
Book Title: Fanconi Anemia & Oxidative Stress
Number of Pages: 143 Pages
Publication Name: Fanconi Anemia & Oxidative Stress: Mechanistic Background & Clinical Prospects
Language: English
Publisher: NOVA Science Publishers Inc
Item Height: 230 mm
Subject: Medicine
Publication Year: 2015
Type: Textbook
Item Weight: 448 g
Author: Giovanni Pagano
Item Width: 155 mm
Format: Hardcover
