Familial Breast and Ovarian Cancer Genetics, Screening and Management Morrison

Description: Familial Breast and Ovarian Cancer Genetics, Screening and Management This book surveys the diagnosis, genetics, screening, prevention and management of familial breast cancer. Patrick J. Morrison (Edited by), Shirley V. Hodgson (Edited by), Neva E. Haites (Edited by) 9780521803731, Cambridge University Press Hardback, published 7 November 2002 418 pages 25.5 x 18 x 2.7 cm, 1.08 kg ' … members of the cancer genetics team who found it immediately useful … the usefulness of the text is such that I found myself reading it from cover to cover. No chapter is weak … I recommend it to all clinical geneticists working in cancer genetics, to breast surgeons and gynaecologists who deal with these cancers, and to radiologists involved in screening programmes. It provides an excellent review of the state of the art, with all the relevant references. Journal of the Royal Society of Medicine This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in our understanding of the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in the diagnosis, genetics, screening, prevention and management of familial breast cancer. This area has advanced in knowledge so rapidly that this publication provides an unrivalled source of information including sections on ethical and insurance issues and the different cultural differences in breast cancer. The use of recently devised cancer genetics clinics and different referral criteria and patterns to these clinics are detailed. The volume will be of immense value to all clinical geneticists, oncologists, and healthcare professionals involved in screening and counselling programmes. Part I. Molecular Biology and Natural History: 1. Introduction Patrick Morrison, Shirley Hodgson and Neva Haites 2. Overview of clinical genetics of breast cancer Neva Haites and Helen Gregory 3. Cowden syndrome and related disorders Charis Eng 4. Overview of clinical genetics of ovarian cancer Pierre Chappuis and Will Foulkes 5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes Hans Vasen and M. A. Nooy 6. Natural history of hereditary breast cancer Dominique Stoppa-Lyonnet, Will Foulkes and Pierre Chappuis 7. Pathology of the breast and ovary in mutation carriers Sunil Lakhani and Adrienne M. Flanagan 8. Risk estimation for familial breast and ovarian cancer Jenny Chang-Claude and Heiko Becher Part II. Screening: 9. Experience of setting up a cancer genetics service Jonathon Gray 10. Referral criteria for cancer genetics clinics Diana Eccles 11. Service aspects of cancer genetic clinics Neva Haites and Shirley Hodgson 12. Cultural and education aspects influencing development of cancer genetics services in different European countries Shirley Hodgson 13. Screening, detection and survival patterns of breast and other cancers in high risk families Pål Møller and Michael Steel 14. Screening for familial ovarian cancer Barnaby Rufford, Usha Menon and Ian Jacobs Part III. Management: 15. Management of BRCA 1/2 mutation carriers Pierre Chappuis and Will Foulkes 16. Management of ovarian cancer Dirk Brinkman and Ian Jacobs 17. Prophylactic mastectomy in mutation carriers Gareth Evans, Fiona Lalloo and Andrew Balidam 18. Psychosocial aspects of genetic counselling Steven Sutton and Alison Bish 19. BRCA 1 and 2 testing: uptake and its measurement Lucy Brooks and Gareth Evans 20. Ethical aspects Patrick Morrison and Michael Steel 21. Gene therapy of breast and ovarian cancer Richard Kennedy and Patrick Johnston 22. Future directions Patrick Morrison, Shirley Hodgson and Neva Haites. Subject Areas: Oncology [MJCL], Medical genetics [MFN], Epidemiology & medical statistics [MBNS]

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