Escherichia coli, a Versatile Pathogen by Gad Frankel (English) Hardcover Book

Description: Escherichia coli, a Versatile Pathogen by Gad Frankel, Eliora Z. Ron coli pathotypes can cause intestinal and extra intestinal infections (e.g. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targetsand development of vaccines that offer lasting protection.This volume focuses on several types of E. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targetsand development of vaccines that offer lasting protection.This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development. Back Cover Escherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli , and in related vaccine development. Author Biography Prof. Dr. Gad FrankelDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom, Prof. Dr. Eliora Z. RonDepartment of Molecular Microbiology and Biotechnology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, Table of Contents Shigella and enteroinvasive Escherichia coli.- Enteroaggregative Escherichia coli.- The Type III Secretion System of pathogenic Escherichia coli.- Modulation of host cell processes by T3SS effectors.- The 2011 German enterohemorrhagic Escherichia coli O104:H4 outbreak – the danger is still out there.- Extraintestinal Pathogenic Escherichia coli.- Pandemic bacteremic Escherichia coli strains: evolution and emergence of drug resistant pathogens.- Current Trends in Antimicrobial Resistance of Escherichia coli.- Vaccines against Escherichia coli. Feature Provides new insights into the genetics, physiology and pathogenesis of E. coli Broadens readers understanding of the various types of E. coli infections Offers an overview of E. coli as part of the microbial intestinal biofilms, the microbiome and its evolution Details ISBN3319996630 Publisher Springer International Publishing AG Series Current Topics in Microbiology and Immunology Edition 1st ISBN-10 3319996630 ISBN-13 9783319996639 Format Hardcover Imprint Springer International Publishing AG Place of Publication Cham Country of Publication Switzerland Edited by Eliora Z Ron Pages 242 Year 2018 Publication Date 2018-11-13 DEWEY 616.926 Language English DOI 10.1007/978-3-319-99664-6 Series Number 416 UK Release Date 2018-11-13 Author Eliora Z. Ron Edition Description 1st ed. 2018 Audience Professional & Vocational Illustrations 20 Illustrations, color; 20 Illustrations, black and white; VII, 242 p. 40 illus., 20 illus. in color. 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