Cancer Precursors: Epidemiology, Detection, and Prevention by Eduardo L. Franco

Description: Cancer Precursors by Eduardo L. Franco, Thomas E. Rohan, J.F. Fraumeni Minilaparoscopy: A Text Atlas presents the latest techniques in operative laparoscopy using instruments no larger than a few millimeters. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description The purpose of this book is to bring together in one place a discussion of the methodological issues associated with the study of precancerous conditions, as well as reviews of the contributions of descriptive, analytical, and molecular epidemiological research to knowledge about cancer precursors at specific anatomical locations. Such a book is particularly timely, given that the last few years have seen enormous progress in terms of molecular epidemiological research on cancers and their precursors. This research has focused essentially on the early natural history of cancers, by helping to define the etiology of precursor lesions, improving the means of detecting them either directly or via testing of surrogate biomarkers, and by elucidating the role of remote causes leading to the early onset of such lesions. and prostate, as well as chapters on screening, chemoprevention and treatment. Cancer Precursors is a groundbreaking, multidisciplinary text for oncologists, epidemiologists, cancer researchers, pathologists, geneticists, molecular biologists, and graduate students in the cancer-related fields. Notes This groundbreaking, multi-disciplinary title focuses on detection, measurement and interpretation of cancer precursors (defined as any lesion up to but not including invasive cancer, e.g. polyps as a pre-invasive lesion leading to colon cancer) at the most important sites where solid tumors occur, including the esophagus, colon, liver, etc. Evidence-based policy recommendations round out this essential volume of interest to pathologists, epidemiologists, cancer researchers, oncologists, and public health professionals. Table of Contents Site-Specific Precancerous Conditions.- Biological Basis of Carcinogenesis.- Mechanisms and Biological Markers of Carcinogenesis.- Morphology of Cancer Precursor Lesions.- Issues Related to Measurement and Interpretation of Cancer Precursors.- Collection, Processing, and Analysis of Preneoplastic Specimens.- Intermediate Markers in Cancer Research: Theoretical and Practical Issues in the Use of Surrogate Endpoints.- Assessing Epidemiological Relations and the Role of Measurement Errors.- Site-Specific Precancerous Conditions.- Upper Aerodigestive Tract.- Esophagus.- Stomach.- Colon and Rectum.- Anus.- Liver.- Pancreas.- Lung.- Skin.- Breast.- Cervix.- Endometrium.- Ovary.- Vulva and Vagina.- Prostate.- Bladder.- Control of Cancer Precursors.- Screening.- Chemoprevention.- Evidence-Based Policy Recommendations on Screening and Prevention.- Conclusion.- Prospects. Review From the reviews:"Drs. Franco and Rohan bring together a timely and comprehensive set of reviews describing the biologic basis of carcinogenesis, issues related to measurement and interpretation of cancer precursors, site specific precancerous conditions, and control of cancer precursors …The book has several important strengths, most notably the wealth of current information on cancer precursors and related topics provided by an impressive cast of cancer researchers. … it effectively provides specific and compelling reasons for studying cancer precursors, the most up-to-date and comprehensive collection of reviews on the topic, and a realistic picture of the complexities facing research of cancer precursors." —American Journal of Epidemiology"In this book, Drs. Franco and Rohan have succeeded in preparing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer precursors. They have enlisted experts in the field who have contributed authoritative chapters to a wide variety of cancers with emphasis on the etiology and natural history, including the role of environmental and heritable factor that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as clasical cellular pathology, providing a fuller understanding of the casual events and mechanisms that initiate the carcinogenic process."-From the Foreward by Joseph F. Fraumeni, Jr., M.D., M.S.Director, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteNational Institutes of HealthRockville, MD"This first edition text presents epidemiological data on the importance of precursor lesions at all the major anatomical sites. … The strongest and most interesting section of the book is part three, which deals with precursor lesions at each of the important anatomical sites. …The most interesting chapters were those that sought to integrate the epidemiology, pathology and molecular biology of the disease … . Overall, I found this book made interesting reading and certainly some chapters would serve as an excellent reference text." (R Ward, Cancer Forum, Vol. 26 (3), 2002) Long Description Dramatic advances in our understanding of cancer causation have come from epidemiologic and laboratory research, particularly over the past two decades. These developments have included a broadening interest in the critical events that take place during the early stages of the dynamic multistep process leading to - vasive cancer. Increasingly, cancer epidemiologists are pursuing research into the origins and natural history of premalignant lesions, including intermediate or surrogate endpoints, a trend - celerated by the development of molecular technologies that are revolutionizing our understanding of the transformation of normal to malignant cells. There seems little doubt that this emerging knowledge will provide further insights not only into carcinogenic processes, but also into more sensitive methods of early detection and more effective means of prevention. In this book, Drs. Franco and Rohan have succeeded in prep- ing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer p- cursors. They have enlisted experts in the ?eld who have c- tributed authoritative chapters on the precursors to a wide variety of cancers,with emphasis on etiology and natural history,including the role of environmental and heritable factors that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as classical cellular pathology, providing a fuller understanding of the causal events and mechanisms that initiate the carcinogenic process. Review Quote From the reviews:"Drs. Franco and Rohan bring together a timely and comprehensive set of reviews describing the biologic basis of carcinogenesis, issues related to measurement and interpretation of cancer precursors, site specific precancerous conditions, and control of cancer precursors …The book has several important strengths, most notably the wealth of current information on cancer precursors and related topics provided by an impressive cast of cancer researchers. … it effectively provides specific and compelling reasons for studying cancer precursors, the most up-to-date and comprehensive collection of reviews on the topic, and a realistic picture of the complexities facing research of cancer precursors. -American Journal of Epidemiology"In this book, Drs. Franco and Rohan have succeeded in preparing a comprehensive, timely, and critical review of the substantial progress that has been made in our understanding of cancer precursors. They have enlisted experts in the field who have contributed authoritative chapters to a wide variety of cancers with emphasis on the etiology and natural history, including the role of environmental and heritable factor that provoke normal cells to undergo malignant transformation. Epidemiologic data are linked whenever possible to molecular as well as clasical cellular pathology, providing a fuller understanding of the casual events and mechanisms that initiate the carcinogenic process."-From the Foreward by Joseph F. Fraumeni, Jr., M.D., M.S.Director, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteNational Institutes of HealthRockville, MD"This first edition text presents epidemiological data on the importance of precursor lesions at all the major anatomical sites. … The strongest and most interesting section of the book is part three, which deals with precursor lesions at each of the important anatomical sites. … The most interesting chapters were those that sought to integrate the epidemiology, pathology and molecular biology of the disease … . Overall, I found this book made interesting reading and certainly some chapters would serve as an excellent reference text." (R Ward, Cancer Forum, Vol. 26 (3), 2002) Feature Includes supplementary material: sn.pub/extras Description for Sales People This groundbreaking, multi-disciplinary title focuses on detection, measurement and interpretation of cancer precursors (defined as any lesion up to but not including invasive cancer, e.g. polyps as a pre-invasive lesion leading to colon cancer) at the most important sites where solid tumors occur, including the esophagus, colon, liver, etc. Evidence-based policy recommendations round out this essential volume of interest to pathologists, epidemiologists, cancer researchers, oncologists, and public health professionals. Details ISBN0387951881 Author J.F. Fraumeni Language English ISBN-10 0387951881 ISBN-13 9780387951881 Media Book Format Hardcover Year 2002 Imprint Springer-Verlag New York Inc. Place of Publication New York, NY Country of Publication United States Edited by Eduardo L. Franco Affiliation Albert Einstein College of Medicine Short Title CANCER PRECURSORS 2002/E Pages 430 Subtitle Epidemiology, Detection, and Prevention DOI 10.1007/b93082 AU Release Date 2002-01-02 NZ Release Date 2002-01-02 US Release Date 2002-01-02 UK Release Date 2002-01-02 Publisher Springer-Verlag New York Inc. Edition Description 2002 ed. Edition 2002nd Publication Date 2002-01-02 Alternative 9781441929013 DEWEY 616.99407 Audience Undergraduate Illustrations XX, 430 p. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96274576;

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