Antiarrhythmic Drugs by E.M. Vaughan Williams (English) Paperback Book

Description: Antiarrhythmic Drugs by E.M. Vaughan Williams, T.J. Campbell Physicians have to determine whether the new drug works, and pharma cologists how it works. When the general design was complete, prospective contributors were invited to write specific chapters, being provided with a complete list of their coauthors and chosen topics, so that they could avoid overlap. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description The development of a new antiarrhythmic drug involves many people with disparate skills. The organic chemist who makes it is guided not only by the structure-action relations of previous compounds, but by anticipation of a requirement for a particular type of action. In fact several of the best-known antiarrhythmics, including lidocaine, mexiletine, amiodarone and verapamil, were originally synthesized for other purposes. Physicians have to determine whether the new drug works, and pharma cologists how it works. For some years I have believed that there was room for a work which could be understood by all these groups and which could enlighten each about the point of view of the others. Thus when I was invited by Springer-Verlag to prepare a volume in their series Handbook of Experimental Pharmacology, I already had a firm conception of what its form should be. In any multi-author work there are two objectives which cannot always readily be reconciled. The first is to select topics which would relate to each other in a coherent manner. to give a logical and orderly shape to the volume as a whole. The second is to offer authors the greatest possible freedom to express themselves as they wish. When the general design was complete, prospective contributors were invited to write specific chapters, being provided with a complete list of their coauthors and chosen topics, so that they could avoid overlap. Notes Springer Book Archives Table of Contents 1 Cardiac Electrophysiology.- 2 Classification of Antiarrhythmic Actions.- 3 Acute and Chronic Animal Models of Cardiac Arrhythmias.- 4 Classification of Human Arrhythmias.- 5 Successes and Limitations of Antiarrhythmic Drug Therapy.- 6 Distinguishing Potentially Lethal from Benign Arrhythmias.- Antiarrhythmic Therapy.- Class I Agents.- 7 Subclassification of Class I Antiarrhythmic Drugs.- 8 Interaction of Class I Drugs with the Cardiac Sodium Channel.- 9 Clinical Use of Class Ia Antiarrhythmic Drugs.- 10 Clinical Use of Class Ib Antiarrhythmic Drugs.- 11 Clinical Use of Class Ic Antiarrhythmic Drugs.- Class II Agents.- 12a Arrhythmias in the Normal Human Heart.- 12b Adrenergic Arrhythmogenicity.- 13 Antiarrhythmic Properties of Beta-Adrenoceptor Blockade During and After Myocardial Infarction.- Class III Agents.- 14 Class III Antiarrhythmic Action.- 15 Amiodarone: Electropharmacologic Properties.- 16 Sotalol.- 17 Clofilium and Other Class III Agents.- Class IV Agents.- 18 Class IV Antiarrhythmic Agents: Utility in Supraventricular Arrhythmias and Their Proarrhythmic Potential.- Class V Agents.- 19 Specific Bradycardic Agents.- Other Therapies.- 20 Use of Adenosine as an Antiarrhythmic Agent.- 21 Physical and Surgical Treatment of Cardiac Arrhythmias.- Factors Involved in Arrhythmogenesis.- 22 Alpha-Adrenoceptors in Arrhythmogenesis.- 23 Adrenergic Arrhythmogenesis and the Long Q-T Syndrome.- 24a Effects of Cardiac Glycosides at the Cellular Level.- 24b Clinical Efficacy of Cardiac Glycosides for Arrhythmias.- 25 Eicosanoids and Arrhythmogenesis.- 26 Possible Role of Lipids and of Free Radicals in Arrhythmogenesis.- 27 Clinical and Pharmacological Characterization and Treatment of Potentially Malignant Arrhythmias of Chronic Chagasic Cardiomyopathy.- 28 Autonomic Mechanisms in Cardiac Rhythm and Arrhythmias.- Epilogue.- Epilogue. Promotional Springer Book Archives Long Description The development of a new antiarrhythmic drug involves many people with disparate skills. The organic chemist who makes it is guided not only by the structure-action relations of previous compounds, but by anticipation of a requirement for a particular type of action. In fact several of the best-known antiarrhythmics, including lidocaine, mexiletine, amiodarone and verapamil, were originally synthesized for other purposes. Physicians have to determine whether the new drug works, and pharma Details ISBN3642736688 Short Title ANTIARRHYTHMIC DRUGS SOFTCOVER Series Handbook of Experimental Pharmacology Language English ISBN-10 3642736688 ISBN-13 9783642736681 Media Book Format Paperback Series Number 89 Year 2011 Publication Date 2011-12-10 Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany Pages 650 Illustrations XXIX, 650 p. DOI 10.1007/978-3-642-73666-7 Author T.J. Campbell Edited by E.M. Vaughan Williams Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Edition Description Softcover reprint of the original 1st ed. 1989 Alternative 9783540192398 DEWEY 616.128061 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96327139;

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