A Clinician's Pearls & Myths in Rheumatology by John H. Stone (English) Hardcove

Description: A Clinician's Pearls & Myths in Rheumatology by John H. Stone This book builds upon the first edition with new and improved chapters. The book explores the rich assemblage of clinical wisdom from expert rheumatologists from a wide range of specialties including Vasculitis and Sjogrens syndrome. It examines the nuggets or pearls of wisdom gained from collective clinical experience about the diagnosis or treatment of various diseases whilst also aiming to debunk myths that have influenced the practice of rheumatology by many clinicians. The second edition of A Clinicians Pearls and Myths in Rheumatology is a critical resource for both practitioners and students of rheumatology. This book provides a clear guide for those wishing to take a "deep dive" into the diagnostic and therapeutic elements of rheumatology. FORMAT Hardcover LANGUAGE English CONDITION Brand New Back Cover This book builds upon the first edition with new and improved chapters. The book explores the rich assemblage of clinical wisdom from expert rheumatologists from a wide range of specialties including Vasculitis and Sjogrens syndrome. It examines the nuggets or pearls of wisdom gained from collective clinical experience about the diagnosis or treatment of various diseases whilst also aiming to debunk myths that have influenced the practice of rheumatology by many clinicians. The second edition of A Clinicians Pearls and Myths in Rheumatology is a critical resource for both practitioners and students of rheumatology. This book provides a clear guide for those wishing to take a "deep dive" into the diagnostic and therapeutic elements of rheumatology. Author Biography John H. Stone MD, MPH. Professor of Medicine, Harvard Medical School. The Edward A. Fox Chair in Medicine, Massachusetts General Hospital, Boston, MA, USA. He writes: I have had a career-long interest in teaching, research, and clinical care of patients with rheumatic diseases; i.e., inflammatory diseases mediated by patients overly active immune systems. My work has focused on the systemic vasculitides, particularly ANCA-associated vasculitis and giant cell arteritis; IgG4-related disease (IgG4-RD); and glucocorticoid toxicity. Following medical school at Harvard Medical School, internal medicine training at Johns Hopkins, and a rheumatology fellowship at the University of California-San Francisco, I co-founded and directed the Vasculitis Center at Johns Hopkins University. This Center was the first in the United States to focus on inflammatory diseases of blood vessels such as ANCA-associated vasculitis and giant cell arteritis. At JohnsHopkins, I directed the first NIH-funded, multi-center clinical trial in granulomatosis with polyangiitis. The results of this trial were published in The New England Journal of Medicine (2005). This trial paved the way for subsequent trials and investigations in vasculitis on an international scale. Work at the Johns Hopkins Vasculitis Center blazed a path for physicians all over the world interested in vasculitis, encouraging them to focus on research in this area. This effort ultimately served as the impetus for dozens of clinical trials in these diseases that have led to substantially better treatments for patients in less than 20 years.In 2008, I was recruited to become the Director of Clinical Rheumatology at the Massachusetts General Hospital (MGH), where I have continued my interest in vasculitis from the research standpoint and broadened my clinical scope to include the full breadth of rheumatology. I was the Co-Principal Investigator on the Rituximab in ANCA-associated Vasculitis (RAVE) trial, funded by the Immune Tolerance Network at the NIH. This trial led to two New England Journal of Medicine papers and changed the standard of care for remission induction in this disease. RAVE formed the basis of approval of rituximab (Rituxan) by the U.S. Food & Drug Administration (FDA), the European Medicines Agency (EMA) for remission induction in ANCA-associated vasculitis. I have also been the global Principal Investigator of a multi-center clinical trial of interleukin-6 receptor (IL6R) blockade in giant cell arteritis. Giant cell arteritis is a disease that currently affects 300,000 Americans, and aside from prednisone there had been no other effective therapy known for nearly seventy years. The trial, known as GiACTA. This trial, conducted at 76 sites across North America and Europe, ledto a "breakthrough designation" for tocilizumab by the FDA for giant cell arteritis and approval by the agency in 2017. The drug has also been approved in Europe for giant cell arteritis, and in Japan it is approved for Takayasus arteritis, a related form of vasculitis, as well – all on the strength of this one trial. The primary results of this trial were published in The New England Journal of Medicine (2017). The trial demonstrated for the first time ever the availability of an effective steroid-sparing approach to the treatment of giant cell arteritis. My second major research interest pertains to an emerging disease, IgG4-RD. My group at the MGH has identified several new disease associations with IgG4-RD, including lymphoplasmacytic thoracic aortitis, eosinophilic angiocentric fibrosis, Riedels thyroiditis, and midline destructive disease. My group also made the novel observation that B cell depletion with rituximab leads to swift, targeted declines in serumIgG4 concentrations (the other IgG subclasses remain stable), associated with dramatic clinical improvement. I was the first author on an NEJM Mechanisms of Disease paper in 2012 entitled "IgG4-Related Disease" and the senior author on a Lancet review (2014). I was the Principal Investigator on an NIH-funded R13 grant to conduct the worlds first International Symposium on IgG4-RD (2011). Three subsequent international symposia on IgG4-RD have followed, and a fifth is planned.Finally, a burgeoning research interest in the last couple of years pertains to the measurement and prevention of steroid toxicity. Steroids remain the cornerstone of treating many immune-mediated diseases, but their toxicities are well-known and generally reviled by physicians and patients alike. I organized an international group of sub-specialty experts to create a Glucocorticoid Toxicity Index (GTI), designed for use as an outcome measurein clinical trials. We have created a version of this instrument designed for use in adult patients that has now been licensed for use in clinical trials across twenty disease indications. A pediatric version of the instrument has also been developed, and both instruments are available on digital platforms.One of the career achievements of which I am most proud, however, is A Clinicians Pearls & Myths in Rheumatology, now in its second edition. This book involves a collaboration of more than 200 international experts who share their insights about this remarkable specialty of ours. Over the span of my career, I have had the privilege of witnessing and in some cases helping in the transition of treatment for patients with inflammatory diseases – rheumatoid arthritis, lupus, vasculitis, IgG4-RD, and many more – out of the Dark Ages of limited therapeutic options with toxic side-effects, into an era of safe, highly effective medications. We have made great progress thus far, and I anticipate an acceleration of the pace between now and the third edition of A Clinicians Pearls & Myths. Table of Contents Rheumatoid Arthritis.- Rheumatoid Vasculitis.- Adult-Onset Stills Disease.- Juvenile Idiopathic Arthritis.- Monogenic Autoinflammatory Syndromes.- Juvenile Spondyloarthropathy.- Ankylosing Spondylitis.- Psoriatic Arthritis.- Reactive Arthritis.- Systemic Sclerosis (Scleroderma) and Raynauds Phenomenon.- Nephrogenic Systemic Fibrosis and Other Scleroderma Mimickers.- Sjögrens Syndrome.- Systemic Lupus Erythematosus.- Pediatric Systemic Lupus Erythematosus.- Mixed Connective Tissue Disease.- The Antiphospholipid Syndrome.- Pregnancy in the Rheumatic Diseases.- Inflammatory Myopathies.- Juvenile Dermatomyositis.- Vasculitic Neuropathy.- Pediatric Vasculitis.- Behçets Syndrome.- The Churg—Strauss Syndrome.- ANCA-Associated Vasculitis.- Cryoglobulinemia.- Polyarteritis Nodosa.- Giant Cell Arteritis and Polymyalgia Rheumatica.- Takayasus Arteritis.- Primary Angiitis of the Central Nervous System and Reversible Cerebral Vasoconstriction Syndromes.- Thromboangiitis Obliterans (Buergers Disease).- Less Common Forms of Vasculitis.- Relapsing Polychondritis.- Fibromyalgia.- The Clinical Features of Gout.- Gout Epidemiology.- Gout Treatment.- Calcium Pyrophosphate Dihydrate (CPPD) Crystal Deposition Disease.- Inflammatory Eye Disease.- Immune-Mediated Inner Ear Disease.- Osteoporosis.- Pagets Disease of Bone.- Sarcoidosis.- Osteoarthritis.- Regional Musculoskeletal Complaints.- Low Back and Neck Pain.- Amyloidosis.- The Ehlers—Danlos Syndrome.- Osteonecrosis. Long Description Important strides have been made in understanding the pathophysiologic basis of many inflammatory conditions in recent years, but rheumatology remains a discipline in which diagnosis is rooted in the medical history skillfully extracted from the patient, the careful physical examination, and the discriminating use of laboratory tests and imaging. Moreover, selection of the most appropriate therapy for patients with rheumatic diseases also remains heavily reliant upon clinical experience.Medical disciplines such as rheumatology that depend significantly upon clinical wisdom are prone to the development of systems of Pearls and Myths, related to the diseases they call their own, a Pearl being a nugget of truth about the diagnosis or treatment of a particular disease that has been gained by dint of clinical experience and a Myth being a commonly held belief that influences the practice of many clinicians - but is false.This book will pool together the clinical wisdom of seasoned, expert rheumatologists who participate in the care of patients with autoimmune diseases, systemic inflammatory disorders, and all other rheumatic conditions. Feature Examines the nuggets of wisdom, pearls gained from collective clinical experience Features the thoughts of many rheumatic diseases Debunks false myths that have influenced clinical practice Details ISBN3031234871 Publisher Springer International Publishing AG Language English Year 2023 Edition 2nd ISBN-10 3031234871 ISBN-13 9783031234873 Format Hardcover DEWEY 616.723 DOI 10.1007/978-3-031-23488-0 Author John H. Stone Imprint Springer International Publishing AG Place of Publication Cham Country of Publication Switzerland Edited by John H. Stone Pages 771 Publication Date 2023-03-31 UK Release Date 2023-03-31 Edition Description 2nd ed. 2023 Replaces 9781848009332 Alternative 9783031234903 Audience Professional & Vocational Illustrations 320 Illustrations, color; 106 Illustrations, black and white; XXIII, 771 p. 426 illus., 320 illus. in color. We've got this At The Nile, if you're looking for it, we've got it. 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